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AI-10-49 - CAS# 1256094-72-0 60268 5 dione (TDZD-8)

SKU: 88067708117

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Description

5 dione (TDZD-8)

41(5):1192-9

This effect is due to increased mean channel closed time without changing mean channel open time

EXP3174 inhibits the angiotensin II-induced cell protein synthesis with an IC50 of 3 nM

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor

AI-10-49 - CAS# 1256094-72-0 60268 5 dione (TDZD-8)AI 10 49, CAS No. 1256094 72 0, is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the

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