Capsazepine - CAS# 138977-28-3 116VP-QAV-572 5-25 mg/Kg to a panel

5-25 mg/Kg to a panel of human-patient-derived and cell-line-derived xenograft (PDX and CDX

CAS Number: 854001-07-3

and apoptotic ratio compared with those in the IR+Mel group

Maximal killing occurred in the presence of 3 to 10 nM Rimiducid (AP1903)

62(19):8784-8795

Capsazepine - CAS# 138977-28-3 116VP-QAV-572 5-25 mg/Kg to a panelCapsazepine is TRPM8 a antagonist. Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is therefore considered to be a capsaicin antagonist. The TRPV1 channel functions as a pain and temperature sensor in mammalians. Capsazepine blocks only the activation of TRPV1 channels by chemicals but not by other painful stimuli, like heat. Depending on the