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PubMed PMID: 24658665
I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET
treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls
but does not activate ASK1/JNK in Ramos cells
4 nM) and 26 ALK resistance mutations
MK-8353 Catalog No.:M19981-C PubMed PMID: 24658665MK 8353 (SCH900353) is a potent, selective and orally available ERK1 2 inhibitor, with IC50s of 23. 0 nM and 8. 8 nM, respectively; MK 8353 has antitumor activity. Product information CAS Number: 1184173 73 6 Molecular Weight: 691. 84 Formula: C37H41N9O3S Chemical Name: (3S) 1 (2 {4 [4 (1 methyl 1H 1,2,4 triazol 3 yl)phenyl] 1,2,3,6 tetrahydropyridin 1 yl} 2 oxoethyl) 3 (methylsulfanyl) N {3 [6 (propan 2 yloxy)pyridin 3 yl] 1H indazol 5 yl}pyrrolidine