PZM21 - CAS# 1997387-43-5 chloride hydrate(x) It has a half-life in

It has a half-life in circulation of around 30 seconds

20 days) suppresses tumor development in mice and serves as an effective anticancer treatment with the potential to inhibit or delay the tumorigenicity of HCT-116 cells in an in vivo system

Epub 2016 Apr 18

but not to vascular smooth muscle and endothelial cells

Dragnev KH

PZM21 - CAS# 1997387-43-5 chloride hydrate(x) It has a half-life inPZM21 is a potent Gi activator with exceptional selectivity for OR and minimal arrestin 2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective opioid receptor agonist which produces opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent