SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid DASA-58 inhibits LPS-induced Hif-1α and

DASA-58 inhibits LPS-induced Hif-1α and IL-1β

ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32

Smiles: CCN1C=C(C2SC(=CC=2C1=O)C(=N)NC1CCS(=O)(=O)CC1)C1=CC(=CC=C1)C(F)(F)F

PFI-3 is a very useful chemical probe to study the key chromatin remodeling and transcription control

is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM

SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid DASA-58 inhibits LPS-induced Hif-1α andSAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low