VX-222 cis - CAS# 1026785-59-0 Laurdan TL12-186 (1-10000 nM

Name: VX-222 cis - CAS# 1026785-59-0 Laurdan TL12-186 (1-10000 nM
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Description

TL12-186 (1-10000 nM

VX-222 cis - CAS# 1026785-59-0 Laurdan TL12-186 (1-10000 nMLomibuvir, also known as VX 222, VCH 222 and VX22, is an nonnucleoside NS5B polymerase inhibitor. VX 222 inhibits the 1b Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX 222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX 222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1

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